Predictive analysis of dyslipidemia in non-obese and lean individuals using body composition analyzer
Keywords:
dyslipidemia, non-alcoholic fatty liver, human body compositionAbstract
Objective: The aim is to examine the predictive value of body composition analysis and anthropometry for dyslipidemia and NAFLD in non-obese and lean individuals.
Method: A descriptive study was conducted to select non-obese and lean individuals who received nutritional counseling at our hospital's nutrition department from January 2023 to December 2023 and were assessed by professional clinical nutritionists for anthropometric measurements. Applying the bioelectrical impedance method to analyze human body composition involves collecting medical history data and laboratory test results. Comprehensively analyze the impact of human body composition analysis and anthropometric indicators on the risk of blood lipids and non-alcoholic fatty liver disease (NAFLD) in non-obese and lean individuals.
Results: The final analysis included 190 individuals. The detection rate of abnormal FPG metabolism was 21.1%, the overall detection rate of abnormal blood lipid metabolism was 58.9%, and the detection rate of abnormal sugar and lipid metabolism was 85.3%. FPG is positively correlated with WHR and the risk of NAFLD. TC is positively correlated with PBF, the risk of NAFLD, and WHR. TG is positively correlated with the risk of NAFLD and negatively correlated with SMM and SMI. LDL-C is positively correlated with PBF, WHR, and the risk of NAFLD. HDL-C is negatively correlated with the risk of NAFLD and WHR, and positively correlated with SMM. PBF is an independent risk factor for increased FPG and TC, and it has a significant impact on HDL (P < 0.05).
Conclusion: Non-obese and lean individuals also have a risk of hyperlipidemia and non-alcoholic fatty liver disease (NAFLD). PBF measured by human body composition analysis and WHR, SMM, and SMI obtained from human body measurements are closely related to each other. They have reference value for alerting to blood lipid abnormalities and monitoring blood lipid levels.
References
1. Nanna MG, Wang TY, Xiang Q, et al. Sex differences in the use of statins in community practice. Circ Cardiovasc Qual Outcomes 2019;12(8):e005562.
2. Wei J, Yang Q, Wang X, et al. Association between homocysteine levels and hyperlipidemia prevalence as well as all-cause mortality of hyperlipidemia patients in the US population: results from NHANES database. Front Cardiovasc Med 2024;25(11):1419579.
3. Abera A, Worede A, Hirigo AT, et al. Dyslipidemia and associated factors among adult cardiac patients: a hospital-based comparative cross-sectional study. Eur J Med Res 2024;29(1):237.
4. Duseja A, De A. Special population: lean nonalcoholic fatty liver disease. Clin Liver Dis 2023;27(2):451–69.
5. Powell EE, Wong VW, Rinella M. Non-alcoholic fatty liver disease. Lancet 2021;397(10290):2212–2224.
6. Sakers A, De Siqueira MK, Seale P, et al. Adipose-tissue plasticity in health and disease. Cell 2022;185(3):419–46.
7. Xu R, Pan J, et al. Recent advances in lean NAFLD. Biomed Pharmacother 2022;153:113331.
8. Long MT, Noureddin M, Lim JK. AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review. Gastroenterology. 2022 Sep;163(3):764-774.e1. doi: 10.1053/j.gastro.2022.06.023.
9. Semmler G, Wernly S, Bachmayer S, et al. Nonalcoholic fatty liver disease in lean subjects: associations with metabolic dysregulation and cardiovascular risk—a single-center cross-sectional study. Clin Transl Gastroenterol 2021;12:e00326.
10. Kanwal F, Shubrook JH, Adams LA, et al. Clinical care pathway for the risk stratification and management of patients with nonalcoholic fatty liver disease. Gastroenterology 2021;161:1657–69.
11. Ren TY, Fan JG. What are the clinical settings and outcomes of lean NAFLD? Nat Rev Gastroenterol Hepatol 2021;18:289–90.
12. Weeks M, Delgado AD, et al. Relationships between body composition, anthropometrics, and standard lipid panels in a normative population. Front Cardiovasc Med 2023;6(10):1280179.
13. Boris D, Av R, George B, et al. Classification and diagnosis of diabetes: standards of medical care in diabetes-2022. Diabetes Care 2022;45:S17–S38.
14. Joachim DH, Jana W, Laurent C, et al. A comparative and sex-specific study of bio-electrical impedance analysis and dual energy X-ray absorptiometry for estimating whole-body and segmental body composition in healthy young adults. Appl Sci 2022;12(15):7686.
15. Virani SS, Alonso A, Benjamin EJ, et al. Heart-disease and stroke statistics – 2020 update: a report from the American Heart Association. Circulation 2020;141(9):e139–e596.
16. Wooten JS, Webb BL, DiMarco NM, Nichols DL, Sanborn CF. Impact of Menopause and Body Composition Status on Dyslipidemia in Women. Am J Health Behav. 2021 Jan 1;45(1):71-80. doi: 10.5993/AJHB.45.1.6.
17. Oliosa PR, Zaniqueli DDA, Barbosa MCR, Mill JG. Relationship between body composition and dyslipidemia in children and adolescentes. Cien Saude Colet. 2019 Sep 26;24(10):3743-3752. Portuguese, English. doi: 10.1590/1413-812320182410.17662017.
18. Chan KE, Koh TJL, Tang ASP, et al. Global prevalence and clinical characteristics of metabolic-associated fatty liver disease: a meta-analysis and systematic review of 10739607 individuals. J Clin Endocrinol Metab 2022;107(9):2691–700.
19. Wong VW, Wong GL, Woo J, et al. Impact of the new definition of metabolic associated fatty liver disease on the epidemiology of the disease. Clin Gastroenterol Hepatol 2021;19(10):2161–71.
20. Chen M, Cao Y. Lean nonalcoholic fatty liver disease and sarcopenia. Front Endocrinol (Lausanne) 2023;14:1217249.
21. Maier S, Wieland A, Cree-Green M, et al. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord 2012;22:351–66.
22. Young S, Tariq R, Provenza J, et al. Prevalence and profile of nonalcoholic fatty liver disease in lean adults: systematic review and meta-analysis. Hepatol Commun 2020;4:953–972.
23. Ren TY, Fan JG. What are the clinical settings and outcomes of lean NAFLD? Nat Rev Gastroenterol Hepatol 2021;18:289–290.
24. Cheng YM, Kao JH, Wang CC. The metabolic profiles and body composition of lean metabolic associated fatty liver disease. Hepatol Int 2021;15:405–412.
25. Gofton C, Clark-Dickson M. Lean metabolic-associated fatty liver disease. Endocrinol Metab Clin North Am 2023;52(3):431–444.
26. Chrysavgis L, Ztriva E. Nonalcoholic fatty liver disease in lean subjects: prognosis, outcomes and management. World J Gastroenterol 2020;26(42):6514–6528.
27. Luukkonen PK, Tukiainen T, Juuti A, et al. Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight 2020;5.
28. Papadopoulou SK, Voulgaridou G, Kondyli FS, et al. Nutritional and nutrition-related biomarkers as prognostic factors of sarcopenia, and their role in disease progression. Diseases 2022;10(3):42.
29. Miyake T, Miyazaki M, Yoshida O, et al. Relationship between body composition and the histology of non-alcoholic fatty liver disease: a cross-sectional study. BMC Gastroenterol 2021;21(1):170.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Fujie Wang, Ting Zhao, Weiwei wang, Qianqian Dai, Qiaoqiao wang, Xianghua Ma, Lin Jiang

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.