Antihypoxic, nephroprotective and antioxidant properties of hydro-alcoholic extract of loquat flowers

Antihypoxic, nephroprotective and antioxidant properties of hydro-alcoholic extract of loquat flowers

Authors

  • Seyed Fazel Nabavi Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Seyed Mohammad Nabavi Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Akbar Hajizadeh Moghaddam Department of Biology, University of Mazandaran, Babolsar, Iran
  • Claire Hellio School of Biological Sciences, University of Portsmouth, King Henry Building, Portsmouth PO1 2DY, UK
  • Mohammad Ali Ebrahimzadeh Faculty of Pharmacy, Mazandaran University of Medical sciences, Sari, Iran

Keywords:

Free radical, Eriobotrya japonica, Gentamicin, rutin

Abstract

Objectives: Loquat is well known Chinese medicinal herb with numerous traditional usages. The fact of the promising effect of loquat on different diseases is approved by a plethora of recent studies. Methods: In the present study antihypoxic, antioxidant and nephroprotective activity of hydro-alcoholic extract of Eriobotrya japonica flower was an investigated employing different in vivo and in vitro assay system. The chemical analysis of Eriobotrya japonica flowers, using atomic absorption spectroscopy, highlighted the presence of eight elements. Gallic acid, rutin and quercetin were determined by HPLC/DAD. Results: Results indicated that the hydro-alcoholic extract has a protective effect against hypoxia induced lethality in mice. Extract at doses of 200 and 400 mg/kg/day for 10 consecutive days, i.p. gave nephroprotection by changing blood urea nitrogen (BUN), serum urea and creatinine levels. Extract showed good antioxidant and antihemolytic activity in all studied models. Present study demonstrates hydro-alcoholic extract of Eriobotrya japonica as a plant with high biological properties. Conclusion: In conclusion, loquat flowers are potential sources of antioxidant, anti-hypoxic and nephroprotective agents.

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Published

20-10-2015

Issue

Vol. 17 No. 3 (2015)

Section

Original articles

License

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How to Cite

1.
Nabavi SF, Nabavi SM, Hajizadeh Moghaddam A, Hellio C, Ebrahimzadeh MA. Antihypoxic, nephroprotective and antioxidant properties of hydro-alcoholic extract of loquat flowers. Progr Nutr [Internet]. 2015 Oct. 20 [cited 2025 Sep. 28];17(3):255-61. Available from: https://mail.mattioli1885journals.com/index.php/progressinnutrition/article/view/4011