Efficacy of microneedling with PDRN salmon 3% to reduce facial hyperpigmentation: skin hyperpigmentation index (SHI) analysis
Keywords:
microneedling, PDRN salmon, hyperpigmentation, skin hyperpigmentation indexAbstract
Aim: The study aimed to assess the safety and efficacy of microneedling (MN) combined with Polydeoxyribonucleotide (PDRN) Salmon 3% for treating facial hyperpigmentation.
Methods: Two patients, aged 40 and 50, underwent two MN sessions combined with PDRN 3%, spaced 3 weeks apart. Photos were taken before and after each visit, as well as at the final visit (6 weeks after baseline).
Results: Photos were analyzed through a Skin Hyperpigmentation Index (SHI) analysis. Both patients showed improved skin quality, brighter facial skin, and reduced facial hyperpigmentation based on SHI scores. No side effects were noted during or after treatment.
Conclusion: Combined therapy of MN and PDRN 3% shows promising outcomes in improving skin quality and hyperpigmentation. To the best of the author’s knowledge, these are the first reported cases of MN combined with PDRN 3% for reducing hyperpigmentation.
References
1. Bailey AJM, Li HOY, Tan MG, Cheng W, Dover JS. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis. J Am Acad Dermatol. 2022; 86(4):797–810.
2. Du Y, Doraiswamy C, Mao J, et al. Facial skin characteristics and concerns in Indonesia: A cross-sectional observational study. Skin Res Technol. 2022; 28(5):719-728.
3. Huang AH, Chien AL. Photoaging: a Review of Current Literature. Current Dermatology Reports. 2020; 9(1):22-29.
4. Vashi NA, Buainain Castro Maymone M DE, Kundu RV. Aging Differences in Ethnic Skin. 2016; 9(1):31-38.
5. Anand CV, Rao P. Skin care used with microneedling. In Microneedling 2021. p. 41–51.
6. Peng GL. Platelet-Rich Plasma for Skin Rejuvenation: Facts, Fiction, and Pearls for Practice. Vol. 27, Facial Plast Surg Clin North Am. 2019; 27(3):405-411.
7. Lee JC, Daniels MA, Roth MZ. Mesotherapy, Microneedling, and Chemical Peels. Clin Plast Surg. 2016; 43(3):583-595.
8. Alster TS, Graham PM. Microneedling: A review and practical guide. Dermatol Surg. 2018; 44(3):397-404.
9. Shin SH, Lee YH, Rho NK, Park KY. Skin aging from mechanisms to interventions: focusing on dermal aging. Front Physiol. 2023; 14:1195272.
10. Suwanchinda A. Treatment of Hyperpigmentation with Microneedling. In: Elizabeth Bahar Houshmand, editor. Microneedling: Global Perspectives in Aesthetic Medicine. First Edition. Bangkok: John Wiley & Sons Ltd.; 2021. pp. 52–79.
11. Noh TK, Chung BY, Kim SY, et al. Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster. Int J Mol Sci. 2016; 17(9):1448.
12. Squadrito F, Bitto A, Irrera N, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol. 2017; 8:224.
13. Park KY, Seok J, Rho NK, Kim BJ, Kim MN. Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatol Ther. 2016; 29(1):37-40.
14. Bossart S, Cazzaniga S, Willenberg T, et al. Skin hyperpigmentation index: a new practical method for unbiased automated quantification of skin hyperpigmentation. J Eur Acad Dermatol Venereol. 2020; 34(7):e334-e336.
15. Atiyeh BS, Abou Ghanem O, Chahine F. Microneedling: Percutaneous Collagen Induction (PCI) Therapy for Management of Scars and Photoaged Skin-Scientific Evidence and Review of the Literature. Aesthetic Plast Surg. 2021; 45(1):296-308.
16. Hou A, Cohen B, Haimovic A, Elbuluk N. Microneedling: A Comprehensive Review. Vol. 43, Dermatol Surg. 2017; 43(3):321-339.
17. Konicke K, Knabel M, Olasz E. Microneedling in Dermatology: A Review. Plast Surg Nurs. 2017; 37(3):112-115.
18. Mccrudden MTC, Mcalister E, Courtenay AJ, González-Vázquez P, Raj Singh TR, Donnelly RF. Microneedle applications in improving skin appearance. Exp Dermatol. 2015; 24(8):561-566.
19. Kelm RC, Ibrahim O. Utility of platelet-rich plasma in aesthetics. Clin Dermatol. 2022; 40(1):19-28.
20. Yi KH, Winayanuwattikun W, Kim SY, et al. Skin boosters: Definitions and varied classifications. Skin Res Technol. 2024; 30(3):e13627.
21. Khan A, Wang G, Zhou F, et al. Polydeoxyribonucleotide: A promising skin anti-aging agent. Vol. 4, Chinese Journal of Plastic and Reconstructive Surgery. 2022; 4(4):187-193.
22. Kim YJ, Kim MJ, Kweon DK, Lim ST, Lee SJ. Polydeoxyribonucleotide Activates Mitochondrial Biogenesis but Reduces MMP-1 Activity and Melanin Biosynthesis in Cultured Skin Cells. Appl Biochem Biotechnol. 2020; 191(2):540-554.
23. Kim JH, Kwon TR, Lee SE, et al. Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler. Sci Rep. 2020; 10(1):5127.
24. Bossart S, Ramelet AA, Willenberg T, et al. Skin Hyperpigmentation Index Facilitating Quantification of Hyperpigmentation in Clinical Practice Dermatology. 2021; 237(3):486-488.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Vera Vera, I Gusti Ayu Agung Praharsini
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
