Comparison of microneedling and polydeoxyribonucleotide salmon 3% versus microneedling and platelet rich plasma in treating wrinkles and facial hyperpigmentation
Keywords:
microneedling, PRP, Salmon, skin aging, rejuvenationAbstract
Background: As we age, skin wrinkles and facial hyperpigmentation are likely to appear. Microneedling (MN), a minimally invasive procedure, has gained popularity for its efficacy in addressing various concerns on the appearance of the skin. Combining it with additional agents enhances its therapeutic benefits. Polydeoxyribonucleotide (PDRN) Salmon 3% and Platelet-Rich Plasma (PRP) are two promising agents for skin rejuvenation.
Objective: This study aims to compare MN combined with PDRN Salmon 3% versus PRP in treating wrinkles and facial hyperpigmentation.
Methods: A randomized, controlled trial was executed involving 24 women, aged 30-50, with moderate wrinkles and hyperpigmentation. Participants were divided randomly into two experimental sets: Group 1 (MN + PDRN Salmon 3%) or Group 2 (MN + PRP). Both treatments were administered in two sessions, three weeks apart. Assessments were performed at baseline and six weeks after baseline. The outcome was measured using the Lemperle score for wrinkles, and Skin Hyperpigmentation Index (SHI) score for facial hyperpigmentation.
Results: Both groups demonstrated significant reductions in wrinkles and facial hyperpigmentation. Notably, the PDRN group showed a significantly greater reduction in Lemperle scores (p=0.021), while no significant difference was observed in SHI scores between the groups (p=0.758). Adverse effects were minimal and similar between the groups.
Conclusion: MN with PDRN 3% or MN with PRP is an effective therapy in treating mild to moderate wrinkles and hyperpigmentation. While both treatments are effective, MN with PDRN 3% demonstrated a more significant reduction in wrinkle scores compared to MN with PRP. Further research is needed to confirm these findings.
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