Histopathologic overlap between fibrotic sarcoidosis and UIP pattern

Histopathologic overlap between fibrotic sarcoidosis and UIP pattern

Authors

  • Wai Ling Leong Department of Biomedical Imaging, Universiti Malaya Research Imaging Centre (UMRIC), Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
  • Venerino Poletti Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy; Department of Medical Specialties/Pulmonology Unit, G.B. Morgagni-Pierantoni Hospital, Forli, Italy; Department of Respiratory Medicine & Allergy, Aarhus Universitet, Aarhus, Denmark
  • Claudia Ravaglia Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy; Department of Medical Specialties/Pulmonology Unit, G.B. Morgagni-Pierantoni Hospital, Forli, Italy
  • Sara Piciucchi Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy; Department of Radiology, G.B. Morgagni-Pierantoni Hospital, Forli, Italy

Keywords:

Fibrotic sarcoidosis, UIP, honeycombing, cryobiopsy

Abstract

N/A

References

1. Patterson KC, Strek ME. Pulmonary fibrosis in sarcoidosis: clinical features and outcomes. Ann Am Thorac Soc. 2013;10(4):362–70. doi:10.1513/AnnalsATS.201303-069FR.

2. Łyżwa E, Wakuliński J, Szturmowicz M, et al. Fibrotic pulmonary sarcoidosis: from pathogenesis to management. J Clin Med. 2025;14(7):2381. doi:10.3390/jcm14072381.

3. Bandyopadhyay D, Mirsaeidi MS. Sarcoidosis-associated pulmonary fibrosis: joining the dots. Eur Respir Rev. 2023;32(169):230085. doi:10.1183/16000617.0085-2023.

4. Verleden SE, Vanstapel A, De Sadeleer L, et al. Distinct airway involvement in subtypes of end-stage fibrotic pulmonary sarcoidosis. Chest. 2021;160(2):562–71. doi:10.1016/j.chest.2021.01.003.

5. Obi ON, Alqalyoobi S, Maddipati V, et al. High-resolution CT scan fibrotic patterns in stage IV pulmonary sarcoidosis: impact on pulmonary function and survival. Chest. 2024;165(4):892–907. doi:10.1016/j.chest.2023.10.021.

6. Desai SR, Sivarasan N, Johannson KA, et al. High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study. Lancet Respir Med. 2024;12(5):409–18. doi:10.1016/S2213-2600(23)00267-9.

7. Kawanobe T, Yamaguchi T, Ishida Y, et al. Fibrotic pulmonary sarcoidosis with honeycomb-like changes mimicking idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) in the lower lobes: a case treated with anti-fibrotic therapy. Intern Med. 2026;65(3):474–8. doi:10.2169/internalmedicine.5537-25.

8. Zhang C, Chan KM, Schmidt LA, et al. Histopathology of explanted lungs from patients with a diagnosis of pulmonary sarcoidosis. Chest. 2016;149(2):499–507. doi:10.1378/chest.15-0615.

9. Churg A, Poletti V, Ravaglia C, et al. Pathological features of connective tissue disease-associated interstitial lung disease in transbronchial cryobiopsies. Histopathology. 2025;86(2):260–7. doi:10.1111/his.15311.

10. Chilosi M, Piciucchi S, Ravaglia C, et al. "Alveolar stem cell exhaustion, fibrosis and bronchiolar proliferation" related entities: a narrative review. Pulmonology. 2025;31(1):2416847. doi:10.1016/j.pulmoe.2024.05.005.

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Published

27-03-2026

Issue

Section

Images in Sarcoidosis

How to Cite

1.
Leong WL, Poletti V, Ravaglia C, Piciucchi S. Histopathologic overlap between fibrotic sarcoidosis and UIP pattern. Sarcoidosis Vasc Diffuse Lung Dis [Internet]. 2026 Mar. 27 [cited 2026 Apr. 17];43(1):18332. Available from: https://mail.mattioli1885journals.com/index.php/sarcoidosis/article/view/18332