Hydrops fetalis associated with SARS-CoV-2 placentitis and de novo CDK13 mutation: an integrated genetic and histological analysis

Valentina Zanin; Giada Piccinin; Flavio Faletra; Catia Mio; Marta Angelini; Maria Orsaria; Carla Pittini; Lorenza Driul

doi:10.23750/abm.v96i3.16128

Hydrops fetalis associated with SARS-CoV-2 placentitis and de novo CDK13 mutation: an integrated genetic and histological analysis

Authors

Valentina Zanin Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy, Department of Medicine, University of Udine, Udine, Italy
Giada Piccinin Department of Pediatrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy, Department of Medicine, University of Udine, Udine, Italy
Flavio Faletra Department of Genetics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy
Catia Mio Department of Medicine, University of Udine, Udine, Italy.
Marta Angelini Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy, Department of Medicine, University of Udine, Udine, Italy
Maria Orsaria Department of Pathological Anatomy, ASUFC University-Hospital of Friuli Centrale, Udine, Italy, Department of Medicine, University of Udine, Udine, Italy
Carla Pittini Department of Neonatology, ASUFC University-Hospital of Friuli Centrale, Udine, Italy, Department of Medicine, University of Udine, Udine, Italy
Lorenza Driul Department of Gynecology and Obstetrics, ASUFC University-Hospital of Friuli Centrale, Udine, Italy, Department of Medicine, University of Udine, Udine, Italy

Keywords:

hydrops fetalis, pregnancy complications, SARS-CoV-2, CDK13 mutation, placenta diseases

Abstract

We present a case of a 33-year-old woman with a diagnosis of hydrops fetalis at 33 weeks gestation. The histopathological examination of the placenta deposes for SARS-CoV-2 placentitis and genetic analysis reveals evidence of a de novo heterozygous mutation of the CDK13 mutation gene in the newborn.

This report presents a case of COVID-19 during pregnancy associated with SARS-CoV-2 placentitis and highlights the characteristic histopathology of this recently described condition, which can lead to hydrops. On the other hand, this is the first reported case of hydrops fetalis in a fetus carrier of a pathogenic CDK13 gene variant. Moreover, since the reported patients with CDK13 mutations and prenatal complications we cannot exclude the causality or at least the contribution of this variant in generating the hydrops

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