Systemic therapies in metastatic pancreatic neuroendocrine neoplasms (PNENs): is there a right sequence? A case report and review of the literature.

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Francesca Spada
Fabio Gelsomino
Annalisa Fontana
Gabriele Luppi
Anna Maria Frezza
Antonio Ungaro
Nicola Fazio

Keywords

PNENs, everolimus, temozolomide, chemotherapy

Abstract

Management of pancreatic neuroendocrine neoplasms (PNENs) is very complex and heterogenous; therefore the right therapeutic strategy closely depends on a multidisciplinary approach. We report a case of 35-years-old man with advanced pancreatic neuroendocrine tumours (PNET). At beginning  individual specialists planned earliest treatments. After disease progression the clinical strategy was handled within a multidisciplinary team and the patient received several therapies thanks to integration of team expertise. The patient died after 7 year from the diagnosis.

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