Diagnostic potential of serum ACE and CBC inflammatory markers in pneumoconiosis in ceramic workers
Keywords:
pneumoconiosis, angiotensin-converting enzyme, CBC inflammatory biomarkersAbstract
This study aims to determine whether serum sACE and CBC inflammatory markers can be used to diagnose pneumoconiosis and assess its severity. 231 subjects(191 working at ceramic sector) referred to XXX Occupational Diseases Polyclinic between January 2021 and January 2024 were classified into pneumoconiosis, non-pneumoconiosis, and control groups. sACE and CBC inflammatory markers were analyzed. ROC curve assessed. sACE levels were markedly elevated(85.19±36.06 U/L) in cases with higher profusion scores and disease categories compared to control and non-pneumoconiosis groups. sACE has a high diagnostic value for pneumoconiosis detection and severity assessment(AUC:0.810,p=0.001). Platelet/Lymphocyte Ratio(PLR) and Monocyte/Lymphocyte Ratio(MLR) were significant predictors of advanced pneumoconiosis with large opacities(AUC for PLR: 0.796, p=0.001; AUC for MLR: 0.726, p=0.004). Serum ACE and CBC inflammatory indices serve as valuable biomarkers for diagnosing pneumoconiosis and determining disease severity.
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