The Value Of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration For The Diagnosis Of Pulmonary Sarcoidosis Real Life-Settings
Keywords:
Sarcoidosis, EBUS, EBUS-TBNA, Endobronchial ultrasound, Real-life settings, Diagnosis, ValueAbstract
Background: Endobronchial ultrasonography-assisted transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique that is used in the diagnosis of mediastinal and hilar lymphadenopathy. The aim of this study was to investigate the diagnostic value of EBUS-TBNA in the diagnosis of sarcoidosis.
Methods: The study included 42 patients who underwent EBUS-TBNA because of suspected sarcoidosis (Grade I and II) on pulmonary radiography and thorax tomography. A total of 104 lymph node stations were sampled from 42 patients.
Results: A diagnosis of sarcoidosis was made histologically in 38 of the 42 patients from whom lymph node sampling was performed with EBUS-TBNA.
Conclusion: EBUS-TBNA was seen to be an extremely successful method in the diagnosis of Grade I and Grade II sarcoidosis. Therefore, EBUS-TBNA should be considered first in the histopathological diagnosis of Grade I and Grade II sarcoidosis.
References
1. Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU. Pulmonary sarcoidosis. Lancet Respir Med. 2018;6(5):389-402.
2. Baughman RP, Wells A. Advanced sarcoidosis. Curr Opin Pulm Med. 2019;25(5):497-504.
3. Spagnolo P, Bernardinello N. Sarcoidosis. Immunol Allergy Clin North Am. 2023;43(2):259-72.
4. Hong G, Lee KJ, Jeon K, et al. Usefulness of endobronchial ultrasound-guided transbronchial needle aspiration for diagnosis of sarcoidosis. Yonsei Med J. 2013;54(6):1416-21.
5. Eckardt J, Olsen K, Jørgensen O. Minimally invasive diagnosis of sarcoidosis by EBUS when conventional diagnosis fail. Sarcoidosis Vasc Diffuse Lung Dis. 2010;27(1):43-8.
6. Murthi M, Donna E, Arias S, et al. Diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in real life. Front Med (Lausanne). 2020;7:118.
7. Wong M, Yasufuku K, Nakajima T, et al. Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis. Eur Respir J. 2007;29:1182-6.
8. Garwood S, Judson MA, Silvestri G, Hoda R, Fraig M, Doelken P. Endobronchial ultrasound for the diagnosis of pulmonary sarcoidosis. Chest. 2007;132:1298-1300.
9. Oki M, Saka H, Kitagawa C, Tanaka S, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration is useful for diagnosing sarcoidosis. Respirology. 2007;12:863-8.
10. Rusch VW, Asamura H, Watanabe H, et al. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4:568-77.
11. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007;357:2153-65.
12. Gilman MJ, Wang KP. Transbronchial lung biopsy in sarcoidosis. An approach to determine the optimal number of biopsies. Am Rev Respir Dis. 1980;122:721-4.
13. Koonitz CH, Joyner LR, Nelson RA. Transbronchial lung biopsy via the fiberoptic bronchoscope in sarcoidosis. Ann Intern Med. 1976;85:64-6.
14. de Boer S, Milne DG, Zeng I, Wilsher ML. Does CT scanning predict the likelihood of a positive transbronchial biopsy in sarcoidosis? Thorax. 2009;64:436-9.
15. Bilaçeroğlu S, Perim K, Günel O, Cağirici U, Büyükşirin M. Combining transbronchial aspiration with endobronchial and transbronchial biopsy in sarcoidosis. Monaldi Arch Chest Dis. 1999;54:217-23.
16. Cho R, Pandey V, Wong J, Keenan J, et al. The role for endobronchial biopsy in the era of endobronchial ultrasound guided transbronchial needle aspiration for the diagnosis of sarcoidosis: a single center experience: Role for EBUS in the diagnosis of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2024;41(2):e2024029.
17. Tsunoda T, Oyama Y. Utility of additional endobronchial biopsy for the diagnosis of sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2024;42(2).
18. Tanrıverdi H, Uygur F, Örnek T, et al. Comparison of the diagnostic value of different lymphocyte subpopulations in bronchoalveolar lavage fluid in patients with biopsy proven sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2016;32(4):305-12.
19. Li K, Jiang S. A randomized controlled study of conventional TBNA versus EBUS-TBNA for diagnosis of suspected stage I and II sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31(3):211-8.
20. Dhooria S, Sehgal IS, Prasad KT, et al. Diagnostic yield and safety of the 19-gauge versus 22-gauge endobronchial ultrasound-guided transbronchial needle aspiration needle in subjects with sarcoidosis (GUESS). Respiration. 2024;103(6):336-43.
21. Mondoni M, D'Adda A, Terraneo S, et al. Choose the best route: ultrasound-guided transbronchial and transesophageal needle aspiration with echobronchoscope in the diagnosis of mediastinal and pulmonary lesions. Minerva Med. 2015;106(5 Suppl 1):13-9.
22. Crombag LMM, Mooij-Kalverda K, Szlubowski A, et al. EBUS versus EUS-B for diagnosing sarcoidosis: the International Sarcoidosis Assessment (ISA) randomized clinical trial. Respirology. 2022;27(2):152-60.
23. Oki M, Saka H, Ando M, et al. How many passes are needed for endobronchial ultrasound-guided transbronchial needle aspiration for sarcoidosis? A prospective multicenter study. Respiration. 2018;95(4):251-7.
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