The Prevalence and associated factors of macrosomia in the Mekong Delta region of Vietnam
Keywords:
Macrosomia, Maternal health, Obesity, Parity, VietnamAbstract
Background and aim: Macrosomia, defined as a birth weight of ≥3,500 grams, presents significant health risks for both mothers and newborns. This study aimed to determine the prevalence and associated risk factors of macrosomia among women delivering at 37 weeks or more at Vinh Long General Hospital in the Mekong Delta, Vietnam.
Methods: A cross-sectional study was conducted from September 2022 to June 2023, including 1,500 participants. Maternal characteristics and pregnancy-related factors were analyzed to identify associations with macrosomia.
Results: The prevalence of macrosomia was 36%, exceeding global averages. Key maternal risk factors included advanced gestational age (≥40 weeks, OR = 1.3, 95% CI: 1.4–2.5, p = 0.02) , parity (OR = 12.4 for single delivery, OR = 3.7 for multiparous women, p < 0.01), and a history of macrosomia (OR = 3.9, p = 0.01). Pre-pregnancy BMI ≥25 kg/m² and excessive gestational weight gain increased the risk by 20.9-fold and 32-fold, respectively.
Conclusions: This study highlights the high prevalence of macrosomia in the Mekong Delta and underscores the importance of maternal weight management and prenatal care. Targeted interventions, including nutritional counseling and early risk assessment, are crucial, especially in rural areas with limited healthcare access. The cross-sectional design limits causal inferences, necessitating future longitudinal studies to assess the long-term effects of maternal health interventions and develop effective prevention strategies. Expanding research to other regions in Vietnam and similar low-resource settings can provide a broader perspective on macrosomia prevention and management.
References
Tela FG, Bezabih AM, Adhanu AK, Tekola KB. Fetal macrosomia and its associated factors among singleton live-births in private clinics in Mekelle city, Tigray, Ethiopia. J BMC pregnancy childbirth. 2019;19:1-6.
Pereda J, Bove I, Pineyro MM. Excessive Maternal Weight and Diabetes Are Risk Factors for Macrosomia: A Cross-Sectional Study of 42,663 Pregnancies in Uruguay. Front Endocrinol (Lausanne). 2020;11:588443.
Modzelewski J, Pokropek A, Jakubiak-Proć M, Muzyka-Placzyńska K, Filipecka-Tyczka D, Kajdy A, et al. Large-for-gestational-age or macrosomia as a classifier for risk of adverse perinatal outcome: a retrospective cross-sectional study. J The Journal of Maternal-Fetal Neonatal Medicine. 2022;35(25):5564-71.
Li L, Chen Y, Lin Z, Lin W, Liu Y, Ou W, et al. Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers. J Peer J. 2020;8:e10123.
Lewandowska M. Maternal Obesity and Risk of Low Birth Weight, Fetal Growth Restriction, and Macrosomia: Multiple Analyses. Nutrients. 2021;13(4):1213.
Lewandowska M. The Role of Maternal Weight in the Hierarchy of Macrosomia Predictors; Overall Effect of Analysis of Three Prediction Indicators. Nutrients. 2021;13(3):801.
Sun Y, Shen Z, Zhan Y, Wang Y, Ma S, Zhang S, et al. Effects of pre-pregnancy body mass index and gestational weight gain on maternal and infant complications. BMC Pregnancy Childbirth. 2020;20(1):390.
Luo L, Zeng H, Zeng M, Liu X, Xu X, Wang L, et al. The second pregnancy has no effect in the incidence of macrosomia: a cross-sectional survey in two western Chinese regions. J Journal of Health, Population Nutrition. 2021;40:1-8.
Du J, Zhang X, Chai S, Zhao X, Sun J, Yuan N, et al. Nomogram-based risk prediction of macrosomia: a case-control study. BMC Pregnancy Childbirth. 2022;22(1):392.
Pillai S, Cheyney M, Everson CL, Bovbjerg ML. Fetal macrosomia in home and birth center births in the United States: Maternal, fetal, and newborn outcomes. Birth. 2020;47(4):409-17.
Lei F, Zhang L, Shen Y, Zhao Y, Kang Y, Qu P, et al. Association between parity and macrosomia in Shaanxi Province of Northwest China. J Italian journal of pediatrics. 2020;46:1-7.
Chen Y-H, Chen W-Y, Chang C-Y, Cho C-Y, Tang Y-H, Yeh C-C, et al. Association between maternal factors and fetal macrosomia in full-term singleton births. J Journal of the Chinese Medical Association. 2023;86(3):324-9.
Moraitis AA, Shreeve N, Sovio U, Brocklehurst P, Heazell AEP, Thornton JG, et al. Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy. PLoS Med. 2020;17(10):e1003190.
Szmyd B, Biedrzycka M, Karuga FF, Rogut M, Strzelecka I, Respondek-Liberska M. Interventricular septal thickness as a diagnostic marker of fetal macrosomia. J Journal of Clinical Medicine. 2021;10(5):949.
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