Paediatric vaccinations: a bibliographic analysis on COVID-19 and influenza

Paediatric vaccinations: a bibliographic analysis on COVID-19 and influenza

Authors

  • Pier Mario Perrone Department of Pathophysiology and Transplantation, University of Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Italy;
  • Gregorio Paolo Milani Department of Clinical Sciences and Community Health, University of Milan, Italy; Pediatric Emergency Units, Fondazione Ca’ Granda Policlinico di Milano, Italy;
  • Silvana Castaldi Department of Biomedical Sciences for Health, University of Milan, Italy; Quality Units, Fondazione Ca’ Granda Policlinico di Milano, Italy;

Keywords:

COVID-19 vaccine, influenza vaccine, paediatric vaccination

Abstract

Background and aim: Vaccinations represent one of the most effective tools for the prevention of disease, as evidenced by the extensive literature on the subject. With COVID-19, this attention has further increased by centralising scientific production. This study aimed to evaluate and compare the literature on the topic of vaccinations for children, with a focus on the differences between the vaccines for influenza and for COVID-19.

Methods: The literature search was conducted by evaluating English-language articles that studied popula-tions under the age of 18 years and excluding non-full papers or articles that did not provide qualitative data. The full-text analysis was conducted for articles published in the three highest IF journals in paediatrics, general medicine and vaccines.

Results: The publication timelines show significant diversity with a peak in 2022 for articles concerning the 2019 novel coronavirus (44.6%) and a constant frequency for articles concerning influenza. Concurrently, the populations examined in the studies exhibit minimal divergence, with North America and Europe representing the predominant regions in both groups.

Conclusions: In light of the multitude of studies examining efficacy and effectiveness, particularly in the context of COIVD-19, the scientific community should direct its attention to the underlying factors that shape perceptions of vaccines, whether hesitancy or acceptance.

References

1. Brandon D, Kimmel M, Kuriyakose SO, Kostanyan L, Mesaros N. Antibody persistence and safety and immunogenicity of a second booster dose nine years after a first booster vaccination with a reduced antigen diphtheria-tetanus-acellular pertussis vaccine (Tdap) in adults. Vaccine. 2018;36(42):6325-33. doi: 10.1016/j.vaccine.2018.08.051.

2. Pourajam S, Kalantari E, Talebzadeh H, et al. Secondary bacterial infection and clinical characteristics in patients with COVID-19 admitted to two intensive care units of an academic hospital in Iran during the first wave of the pandemic. Front Cell Infect Microbiol. 2022;12:784130. doi: 10.3389/fcimb.2022.784130.

3. Castaldi S, Perrone PM, Luconi E, et al. Hospital acquired infections in COVID-19 patients in sub intensive care unit: analysis of two waves of admissions. Acta Biomed. 2022;93(5). doi: 10.23750/abm.v93i5.13402.

4. Genovese C, Costantino C, Odone A, et al. A knowledge, attitude, and perception study on flu and COVID-19 vaccination during the COVID-19 pandemic: multicentric Italian survey insights. Vaccines (Basel). 2022;10(2). doi: 10.3390/vaccines10020142.

5. Lazarus R, Querton B, Corbic Ramljak I, et al. Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in the UK (COV-COMPARE): interim analysis of a randomised, controlled, phase 3, immunobridging trial. Lancet Infect Dis. 2022;22(12):1716-27. doi: 10.1016/S1473-3099(22)00502-3.

6. Ramasamy MN, Minassian AM, Ewer KJ, et al. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. Lancet. 2020;396(10267):1979-93 doi: 10.1016/S0140-6736(20)32466-1.

7. Li G, Cappuccini F, Marchevsky NG, et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6–17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. Lancet. 2022;399(10342):2212-25. doi: 10.1016/S0140-6736(22)00770-X

8. Biganzoli G, Mendola M, Perrone PM, et al. The effectiveness of the third dose of COVID-19 vaccine: when should it be performed? Vaccines. 2024;12:315. doi: 10.3390/vaccines12030315

9. Lecce M, Perrone PM, Bonalumi F, Castaldi S, Cremonesi M. 2020–21 influenza vaccination campaign strategy as a model for the third COVID-19 vaccine dose? Acta Biomed. 2021;92. doi: 10.23750/abm.v92iS6.12230.

10. Perrone PM, Scarioni S, Astorri E, et al. Vaccination open day: a cross-sectional study on the 2023 experience in Lombardy region, Italy. Int J Environ Res Public Health. 2024;21:685. doi: 10.3390/ijerph21060685.

11. Perrone PM, Biganzoli G, Lecce M, et al. Influenza vaccination campaign during the COVID-19 pandemic: the experience of a research and teaching hospital in Milan. Int J Environ Res Public Health. 2021;18:5874. doi: 10.3390/ijerph18115874.

12. Perrone PM, Villa S, Raciti GM, et al. Influenza and COVID-19 vaccination in 2023: a descriptive analysis in two Italian research and teaching hospitals. Is the on-site strategy effective? Ann Ig. 2024;36(4):421-31. doi: 10.7416/ai.2024.2606.

13. Wang S, Xu J, Zhu J. Impact of the COVID-19 pandemic on self-paid vaccination intentions for children: a cross-sectional study in China. BMJ Open. 2024;14(8):e083056. doi: 10.1136/bmjopen-2023-083056.

14. Gurfinkel D, Tietbohl C, Clark E, et al. Perceived effects of COVID-19 on vaccine hesitancy and clinician discussion: a qualitative study. Pediatrics. 2024;154(4):e2024066819. doi: 10.1542/peds.2024-066819.

15. . Adegoke AA, Balogun FM. How the COVID-19 pandemic affected infant vaccination trends in rural and urban communities in Ibadan, Nigeria: a cross-sectional study. BMJ Open. 2024;14(7):e073272. doi: 10.1136/bmjopen-2023-073272.

16. Wang B, Andraweera P, Danchin M, et al. Nudging towards COVID-19 and influenza vaccination uptake in medically at-risk children: EPIC study protocol of randomised controlled trials in Australian paediatric outpatient clinics. BMJ Open. 2024;14(2):e076194. doi: 10.1136/bmjopen-2023-076194

17. Tran L, Dang T, Nguyen M, et al. Behavioural and social drivers of COVID-19 vaccination in Vietnam: a scoping review. BMJ Open. 2023;13(12):e081134. doi: 10.1136/bmjopen-2023-081134.

18. Wee LE, Tang N, Pang D, et al. Effectiveness of monovalent mRNA vaccines against Omicron XBB infection in Singaporean children younger than 5 years. JAMA Pediatr. 2023;177(12):1324-31. doi: 10.1001/jamapediatrics.2023.4505.

19. Li S, Gong T, Chen G, et al. Parental preference for influenza vaccine for children in China: a discrete choice experiment. BMJ Open. 2022;12(6):e055725. doi: 10.1136/bmjopen-2021-055725.

20. Norman DA, Barnes R, Pavlos R, et al. Improving influenza vaccination in children with comorbidities: a systematic review. Pediatrics. 2021;147(3):e20201433. doi: 10.1542/peds.2020-1433.

21. Del Duca E, Chini L, Graziani S, Sgrulletti M, Moschese V, with the Italian Pediatric Immunology and Allergology Society (SIAIP) Vaccine Committee. Pediatric health care professionals' vaccine knowledge, awareness and attitude: a survey within the Italian Society of Pediatric Allergy and Immunology. Ital J Pediatr. 2021;47(1):183. doi: 10.1186/s13052-021-01090-9.

22. Mello MM, Opel DJ, Benjamin RM, et al. Effectiveness of vaccination mandates in improving uptake of COVID-19 vaccines in the USA. Lancet. 2022;400(10351):535-8. doi: 10.1016/S0140-6736(22)00875-3.

23. Khobragade A, Bhate S, Ramaiah V, et al. Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in India. Lancet. 2022;399(10332):1313-21. doi: 10.1016/S0140-6736(22)00151-9.

24. Piechotta V, Harder T. Waning of COVID-19 vaccine effectiveness: individual and public health risk. Lancet. 2022;399(10328):887-9. doi: 10.1016/S0140-6736(22)00282-3.

25. Karafillakis E, Van Damme P, Hendrickx G, Larson HJ. COVID-19 in Europe: new challenges for addressing vaccine hesitancy. Lancet. 2022;399(10326):699-701. doi: 10.1016/S0140-6736(22)00150-7.

26. Omer SB, Benjamin RM, Brewer NT, et al. Promoting COVID-19 vaccine acceptance: recommendations from the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA. Lancet. 2021;398(10317):2186-92. doi: 10.1016/S0140-6736(21)02507-1.

27. Smith J, Lipsitch M, Almond JW. Vaccine production, distribution, access, and uptake. Lancet. 2011;378(9789):428-38. doi: 10.1016/S0140-6736(11)60478-9.

28. Booy R, Rashid H, Yin JK, Khandaker G, Leask J. Mandating influenza vaccination in health-care workers. Lancet. 2011;378(9803):1626. doi: 10.1016/S0140-6736(11)61697-8.

29. Graham RJ, Enriquez LF, Elmi AF, Zavadoski JV, Bielak LG, Baker CD, et al. Influenza and COVID-19 vaccination rates among children receiving long-term ventilation. JAMA Netw Open. 2024;7(8):e2430989. doi: 10.1001/jamanetworkopen.2024.30989

30. SteelFisher GK, Findling MG, Caporello HL, McGowan E, Espino L, Sutton J. Divergent attitudes toward COVID-19 vaccine vs influenza vaccine. JAMA Netw Open. 2023;6(12):e2349881. doi: 10.1001/jamanetworkopen.2023.49881

Downloads

Published

05-08-2025

Issue

Section

CLINICAL REVIEWS, BIBLIOMETRIC ANALYSIS, ARTIFICIAL INTELLIGENCE

How to Cite

1.
Perrone PM, Milani GP, Castaldi S. Paediatric vaccinations: a bibliographic analysis on COVID-19 and influenza. Acta Biomed. 2025;96(4):16579. doi:10.23750/abm.v96i4.16579