Lipid profile, TNF-α, IL-18, hsCRP, and carotid intima-media thickness (CIMT) diameter in relation to insulin resistance of Indonesian adolescents with overweight and severe obesity
Keywords:
Insulin resistance, Lipid Profile, TNF-α, IL-18, CIMTAbstract
Background and Aim: There is an obvious correlation between insulin resistance (IR) in children and adolescents, obesity, and the elements of metabolic syndrome (MetS), which contributes to an increased risk of cardiovascular issues via pro-inflammatory response (TNF-α, IL-18, hsCRP), leading to early atherosclerosis development, marked with carotid intima-media thickness (CIMT). This study aimed to explore the relationships between IR and various factors, including lipid profiles, TNF-α, IL-18, hsCRP, and CIMT in adolescents. Methods: A cross-sectional study was performed between August - December 2023 involving 94 healthy adolescents with obesity. Anthropometric measures and blood biochemistry were done by professional laboratory staff; CIMT diameters were also assessed. IR was established using the HOMA-IR with the parameters of > 5.22 for boys and >3.82 for girls. Results: IR in adolescents with overweight and severe obesity was detected in 26.60% subjects, that much lower than other findings in Southeast Asia and Indonesia and not related to sex. IR subjects had moderate correlation with anthropometric values, including body weight, body mass index (BMI), BMI-for-age Z-score, waist circumference, and hip circumference. In lipid profile, IR had a positive correlation with triglycerides (TG), but a weak negative correlation with HDL. IR had a significant weak correlation with hsCRP and CIMT diameter. Conclusion: IR was positively associated with higher triglycerides (TG), TNF-α, hsCRP levels, and CIMT diameter, while it showed a negative relationship with HDL cholesterol (HDL-c). No significant correlation or difference was observed between IR and serum levels of IL-18. (www.actabiomedica.it)
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