Long COVID in Brazilian healthcare workers: Case-control study on physical and mental health outcomes in northeastern Brazil
Keywords:
long covid, healthcare workers, quality of life, mental health, physical health, case-control studiesAbstract
Long COVID syndrome causes a variety of neurocognitive, respiratory, and cardiac symptoms, which can be persistent and debilitating, which result in significant impacts on quality of life in terms of mental and physical health. In this work, we conducted a case-control study with 53 healthcare workers. The investigation of Long COVID was carried out with the ONS questionnaire and the assessment of quality of life and physical and neuropsychological health with the PROMIS Global 10 questionnaire. Notably, 66.7% of individuals with intense impact on quality of life belonged to the low physical health score group, while 40% belonged to the low mental health group. Out of 53 subjects, 26 were identified with Long Covid, where 7% had a reduction in their mental health score, and the impact on quality of life was intense for 14 and moderate for 11 of them. These results indicate that prolonged Long COVID symptoms have a substantial effect on the quality of life of patients, especially those with low levels of physical and mental health. The study identified significant impacts between intense and moderate on the physical and psychological health of the healthcare professionals studied, highlighting the association with those who had a loss of smell and taste during the acute phase of the infection.
References
1. Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2020;163(1):3-11. doi: 10.1016/j.anl.2021.07.007
2. Centers for Disease Control and Prevention. Long COVID or post-COVID conditions. Atlanta: CDC; 2020. Available from: https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects.html. Accessed: Mar 19, 2021.
3. Sudre CH, Murray B, Varsavsky T, et al. Attributes and predictors of long COVID. Nat Med. 2021;27(4):626-631. doi: 10.1101/2020.10.19.20214494
4. Astin R, Banerjee A, Baker MR, et al. Long COVID: mechanisms, risk factors and recovery. Exp Physiol. 2022;108(1):12-27. doi: 10.1113/EP090802
5. Perumal R, Shunmugam L, Naidoo K, et al. Long COVID: a review and proposed visualization of the complexity of long COVID. Front Immunol. 2023;14:1-18. doi: 10.3389/fimmu.2023.1117464
6. Lim SH, Lim YC, Zaki RA, et al. Prevalence and predictors of post-acute COVID syndrome among infected healthcare workers at University Malaya Medical Centre. PLoS One. 2024;19(4):e0298376.
7. Malesevic S, Sievi NA, Baumgartner P, et al. Impaired health-related quality of life in long-COVID syndrome after mild to moderate COVID-19. Sci Rep. 2023;13:7717. doi: 10.1038/s41598-023-34678-8
8. Nittas V, Gao M, West EA, Ballouz T, Menges D, Hanson SW, et al. Long COVID through a public health lens: an umbrella review. Public Health Rev. 2022;43:1-10. doi: 10.3389/phrs.2022.1604501
9. Fouad MM, Nermin HZ, Lobna AM. Work performance among healthcare workers with post COVID-19 syndrome and its relation to antibody response. Infection. 2023;51(4):839-849.
10. Vélez-Santamaría R, Fernández-Solana J, Méndez-López F, et al. Functionality, physical activity, fatigue and quality of life in patients with acute COVID-19 and long COVID infection. Sci Rep. 2023;13:47218. doi: 10.1038/s41598-023-47218-1
11. Lins ID, Raupp LS, Maior CBS, et al. SerumCovid database: description and preliminary analysis of serological COVID-19 diagnosis in healthcare workers. PLoS One. 2022;17(3):e0265016. doi: 10.1371/journal.pone.0265016
12. Ayoubkhani D, Gaughan C, Jenkins J. Update on long COVID prevalence estimate. ONS; Feb 2021.
13. Zumpano CE, Mendonça TMS, Silva CHM, Correia H, Arnold B, Pinto RMC. Adaptação transcultural e validação da escala de saúde global do PROMIS para a língua portuguesa. Cad Saude Publica. 2017;33(6):e00107616. doi: 10.1590/0102-311X00107616
14. Wanga V, Chevinsky JR, Dimitrov LV, et al. Long-term symptoms among adults tested for SARS-CoV-2. MMWR Morb Mortal Wkly Rep. 2021;70(36):1235-1241. doi: 10.15585/mmwr.mm7036a1
15. Muschi AL, Borges IC, Faria E, et al. Clinical features of COVID-19 by SARS-CoV-2 Gamma variant: a prospective cohort study of vaccinated and unvaccinated healthcare workers. J Infect. 2022;84(3):248-288. doi: 10.1016/j.jinf.2021.09.005
16. Turabian JL. COVID-19 breakthrough infections in vaccinated people with vaccine booster in 2022 versus COVID-19 cases in unvaccinated people in 2020: a new disease whose clinic we should know or another cause of the old symptoms of the common cold. J Gen Med Clin Pract. 2022;5(1):1-7. doi: 10.31579/2639-4162/060
17. Tak CR. The health impact of long COVID: a cross-sectional examination of health-related quality of life, disability, and health status among individuals with self-reported post-acute sequelae of SARS-CoV-2 infection at various points of recovery. J Patient Rep Outcomes. 2023;7:57. doi: 10.1186/s41687-023-00572-0
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Danielly Alves Mendes Barbosa, Ewerton Henrique da Conceição, Maria Renata da Silva Santos, Caio Souto Maior, Isis Lins Didier, Alice Valença Araujo, Ana Lisa do Vale Gomes

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.